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Lennox-Gastaut syndrome (LGS) is a severe form of childhood epilepsy that is defined by generalized multiple types seizures, slowness of intellectual growth, and a specific electroencephalogram disturbance. Which of the following cannabinoids is indicated for the treatment of seizures associated with Lennox-Gastaut syndrome?

A. Nabiximols

B. Nabilone

C. CBD

D. Cannabis

E. THC

Answer: C

THC and CBD are the two primary substances found in cannabis. Nabiximols (Sativex) is extracted THC/CBD used to treat advanced cancer pain, Multiple Sclerosis neuropathic pain or spasticity; Nabilone (Cesamet) is THC analog used to treat severe nausea and vomiting due to cancer chemotherapy, AIDS-related anorexia, palliative pain, and neuropathic pain.

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