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Cannabis math. What is the estimated THC dose if 1 joint containing 0.5 grams of 12% THC dried cannabis is smoked? Assume 50% loss by combustion. 

A. 5 mg

B. 15 mg

C. 30 mg

D. 60 mg

Answer: C

A.  Calculation: 500 mg cannabis x 12% THC = 60 mg

If 50% loss to combustion, then the amount of THC smoke is: 60 mg THC x 50% = 30 mg

Question 2

Mrs. Peter had two episodes of deep vein thrombosis. She has been using warfarin for the past 9 months as a preventive strategy. DVT is the most common type of venous thrombosis. Mrs. Peter is visiting the pharmacy to discuss her interest in recreational cannabis. Which of the following cannabinoids may induce CYP1A2 resulting in decreased levels of warfarin?

A. Vaped cannabis

B. Oral THC/CBD

C. Oral CBD

D. Smoked cannabis

Answer: D

Evidence show that smoking cannabis may potentially cause significant interaction with warfarin mediated by CYP1A2 resulting in increased warfarin clearance, which leads to reduced warfarin effects. There are no reports of interactions between edible cannabis and warfarin.

Additional learning: All cannabinoids have additive CNS effects with alcohol, benzodiazepines, opioids etc.

 

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